Allosteric hemoglobin modifiers to decrease oxygen affinity in b

Details Allosteric hemoglobin modifiers to decrease oxygen affinity in b Allosteric hemoglobin modifiers to decrease oxygen affinity in b

1993-07-30

1995-07-11

Dees, Jose G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514486, 514512, 514513, 514533, 514535, 514538, 514833, 424DIG13, 548403, 548416, 548473, 548478, 560 30, 560 31, 560 32, 562452, 562455, 568452, 568455, A61K 3140, A61K 31325, C07C 4500

Patent

active

054321913

ABSTRACT:
A family of compounds has been found to be useful for right-shifting hemoglobin towards a low oxygen affinity state. The compounds are capable of acting on hemoglobin in whole blood. In addition, the compounds can maintain the oxygen affinity in blood during storage and can restore the oxygen affinity of outdated blood.

REFERENCES:
patent: 5049695 (1991-09-01), Abraham et al.
patent: 5122539 (1992-06-01), Abraham et al.
patent: 5248785 (1993-09-01), Abraham et al.
patent: 5290803 (1994-03-01), Abraham et al.

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