Allosteric hemoglobin modifiers

Details Allosteric hemoglobin modifiers Allosteric hemoglobin modifiers

1990-02-12

1991-09-17

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 30, 560 31, 560 32, 568452, 568455, C07C27100

Patent

active

050496956

ABSTRACT:
Allosteric hemoglobin modifier compounds having the general formula ##STR1## wherein X and Z may be CH.sub.2, NH or O.

REFERENCES:
patent: 4482571 (1984-11-01), Abraham et al.
patent: 4699926 (1987-10-01), Abraham et al.
patent: 4704402 (1987-11-01), Abraham et al.
patent: 4731381 (1988-03-01), Abraham et al.
patent: 4731473 (1988-03-01), Abraham et al.
patent: 4751244 (1988-06-01), Abraham et al.
patent: 4887995 (1989-12-01), Abraham et al.
Chemical Abstract, vol 84, No. 121481a, "Phenoxyalkanoic Acid Derivatives", abstract from DE 2,432,560.
Perutz, "Mechanisms of Cooperativity and Allosteric Regulation in Proteins", Quarterly Review of Biophysics, 22:2 (1989), pp. 139, 163 and 164.
Lalezari et al., "LR16, A Compound with Potent Effects on the Oxygen Affinity of Hemoglobin, on Blood Cholesterol, and on Low Density Lipoprotein", Proc. Natl. Acad. Sci. (U.S.A.) 85 (1988) pp. 6117-6121.
Chemical Abstracts, 25-Noncondensed Aromatics, vol. 79 (1973), pp. 417, No. 1843k which identifies German Patent 2,149,070.
Perutz, "Bezafibrate Lowers Oxygen Affinity of Hemoglobin", The Lancet, Oct. 15, 1983, pp. 881-882.
Pertuz et al., "Hemoglobin as a Receptor of Drugs and Peptides: X-Ray Studies of the Stereochemistry of Binding", J. Amer. Chem. S., vol. 108, (1986), pp. 1064-1078.
Abraham, et al., "Design, Synthesis, and Testing of Potential Antisickling Agents. 4. Structure-Activity Relationships of Benzyloxy and Phenoxy Acids", J. Med. Chem., vol. 27, (1984) pp. 967-978.
Abraham et al., "Design Synthesis, and Testing of Potential Antisickling Agents. 7. Ethacrynic Acid Analogues", J. Med. Chem., vol. 32, (1989), pp. 2460-2467.
Zijlstra et al., "Standardization of Hemoglobinometry. 1. The Extinction Coefficient of Hemiglobincyanide", Clinica Chimica Acta, vol. 5, (1960), pp. 719-726.
Zijlstra et al., "Spectrophotometry of Haemoglobin: The Standard Haemiglobin Cyanide Method and After", J. Clin. Chem. Biochem., vol. 19, (1981), pp. 521-523.
Dozy et al., "Studies on the Heterogeneity of Hemoglobin. XIII. Chromotagraph of Various Human and Animal Hemoglobin Types on DEAE-Sephadex", J. Chrom., vol. 32, (1968) pp. 723-726.
Aminco Hem-O-Scan.TM. Laboratory Manual.
Hemoglobin Structure/Function, lecture by Dr. Abraham on Oct. 3, 1990.

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