Allosteric hemoglobin modifier compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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560 42, C01C22934

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active

053826809

ABSTRACT:
Allosteric hemoglobin modifier compounds having the general structural formula: ##STR1## wherein the R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 moieties may be hydrogen, halogen or alkyl groups and may be the same or different, and wherein the R.sub.7 and R.sub.8 moieties may be hydrogen or methyl groups and may be the same or different.

REFERENCES:
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patent: 4699926 (1987-10-01), Abraham et al.
patent: 4704402 (1987-11-01), Abraham et al.
patent: 4731381 (1988-03-01), Abraham et al.
patent: 4731473 (1988-03-01), Abraham et al.
patent: 4751244 (1988-06-01), Abraham et al.
patent: 4887995 (1989-12-01), Abraham et al.
"Mechanisms of Cooperativity and Allosteric Regulation In Proteins", Quarterly Review of Biophysics, 22:2 (1989), pp. 139, 163 and 164, Perutz.
"LR16, a compound with potent effects on the oxygen affinity of hemoglobin, on blood cholesterol, and on low density lipoprotein", Proc. Natl. Acad. Sci. (USA) 85 (1988), pp. 6117-6121; Lalezarie et al.
Chemical Abstracts, 25-Noncondensed Aromatics, vol. 79 (1973), p. 427, No. 18434k which identifies German Patent 2,149,070.
"Allosteric modifiers of hemoglobin", Abstract #71 in American Chemical Society Division of Medicinal Chemistry, 200th ACS National Meeting, Aug. 26-31, 1990, Randad et al. (1990).
"Bezafibrate Lowers Oxygen Affinity of Hemoglobin", The Lancet, Oct. 15, 1983, pp. 881-882; Perutz (1983).
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"Design, Synthesis, and Testing of Potential Antisickling Agents. 4. Structure-Activity Relationships of Benzyloxy and Phenoxy Acids", J. Med. Chem., vol. 27, (1984), pp. 967-978; Abraham et al.
"Design, Synthesis, and Testing of Potential Antisickling Agents. 7. Ethacrynic Acid Analogues", J. Med. Chem., vol. 32, (1989), pp. 2460-2467; Abraham et al.
"Standardization of Hemoglobinometry. 1. The Extinction Coefficient of Hemiglobincyanide", Clinica Chimica Acta, vol. 5, (1960), pp. 719-726; Zijlstra et al.
"Spectrophotometry of Haemoglobin: The Standard Haemiglobin Cyanide Method and After", J. Clin. Chem. Biochem., vol. 19, (1981), pp. 521-523; Zijlstra et al.
"Studies on the Heterogeneity of Hemoglobin. XIII. Chromotagraphy of Various Human and Animal Hemoglobin Types of DEAE-Sephadex", J. Chrom., vol. 32, (1968), pp. 723-727; Dozy et al.
Hemoglobin Structure/Function, lecture by Dr. Abraham on Oct. 3, 1990.

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