Allosteric conjugates of hemoglobin and use as blood substitutes

Details Allosteric conjugates of hemoglobin and use as blood substitutes Allosteric conjugates of hemoglobin and use as blood substitutes

1984-10-26

1987-10-06

Kight, John

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

Mixing of two or more solid polymers; mixing of solid...

530350, 530402, 530813, 530816, 514 2, 514 6, 514 7, 514 8, 514 54, 514 59, 514 60, C07G 700, C07C10352, A61K 3700, A61K 3171

Patent

active

046983872

ABSTRACT:
The invention relates to an allosterically active conjugate composition comprising one or more hemoglobin tetramers and one or more adducts of a physiologically safe macromolecular agent covalently linked to one or more ligands, such that the adduct is bound to the allosteric binding site of the hemoglobin in a reversible, non-covalent manner; the invention also relates to methods for producing such conjugate compositions; and to blood substitutes or plasma extenders containing such conjugates.

REFERENCES:
patent: 3925344 (1975-12-01), Mazur
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4377512 (1983-03-01), Ajisaka et al.
patent: 4421896 (1983-12-01), Dorman
patent: 4425334 (1984-01-01), Hunt
Tam et al, "Soluble Dextran-Hemoglobin Complex as a Potential Blood Substitute", Proc. Natl. Acad. Sci., vol. 73, No. 6, pp. 2128-2131, Jun. 1976.
Ajisaka et al, "Modification of Human Hemoglobin with Polyethylene Glycol: A New Candidate for Blood Substitute", Biochem. Biophys. Res. Comm., vol. 97, No. 3, pp. 1076-1081, Dec. 1980.

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