Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-30
1997-07-08
Walsh, Stephen G.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530324, 530325, 530326, 530395, 435 691, 4351723, C07K 700, C07K 14705, C12N 1500
Patent
active
056462514
ABSTRACT:
The invention provides purified ARAg polypeptides, antibodies against ARAg polypeptides and nucleic acids encoding ARAg polypeptides. Also provided are methods of diagnosis and treatment using the same. ARAg polypeptides are typically present on the surface of alloantigen-activated CD8.sup.+ T-cells, monocytes, granulocytes and peripheral dendritic cells, and substantially absent on resting T-cells, mitogen-activated CD8.sup.+ T-cells, B-cells, erythroid cell lines, myelomonocitic cell lines, EBV-LCL cell lines and fibroblastoid cell lines. An exemplary ARAg polypeptide, termed ARAg-h-1, has a signal sequence, seven variable-type immunoglobulin-like domains, a transmembrane domain and an intracellular domain.
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Engleman Edgar G.
Laus Reiner
Rivas Alberto
Ruegg Curtis L.
Kemmerer Elizabeth C.
The Board of Trustees of Leeland Stanford Jr. Univ.
Walsh Stephen G.
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