Allocolchinones and uses thereof

Details Allocolchinones and uses thereof Allocolchinones and uses thereof

1996-03-11

1998-06-02

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514683, 514674, 514685, 568325, 568326, A01N 3500, A61K 3112

Patent

active

057600929

ABSTRACT:
Disclosed are allocolchinones, which are anti-mitotic agents. Allocolchinones bind to tubulin reversibly and are more effective at inhibiting microtubule formation than colchicine. 7-Acetamido-allocolchinone inhibits the growth of a number of tumor cell lines at concentrations about 100 times lower than colchicine. Also disclosed is a method of treating an individual with cancer by administering a composition which comprises a therapeutically effective amount of an allocolchinone which inhibits microtubule assembly. Administering a therapeutically effective amount of a composition which comprises an allocolchinone which inhibits microtubule assembly can also be used for treating inflammatory diseases, multiple sclerosis, primary biliary cirrhosis, Alzheimer's Disease and Behcet's Disease.

REFERENCES:
Hastie, S. B., "Spectroscopic and kinetic features of allocolchicine binding to tubulin", Biochemistry, 28(19), pp. 7753-7760, 1989, see abstract, 1989.
Fitzgerald, T. J., "Molecular features of cochicine associated with antimitotic activity and inhibition of tubulin polymerization", Biochem. Pharmacol., 25(12), pp. 1383-1387, 1976, see abstract, 1976.
Andreu, J. M., et al., "Interaction of Tubulin with Bifunctional Colchicine Analogues: An Equlibrium Study," Biochemistry, 23(8):1742-1752 (1984).
Andreu, J. M., et al., "Mechanism of Colchicine Binding to Tubulin. Tolerance of Substituents in Ring C' of Biphenyl Analogues," Biochemistry, 30(15):3777-3786 (1991).
Medrano, F. J., et al., "Roles of Colchicine Rings B and C in the Binding of Process to Tubulin," Biochemistry, 28(13):5589-5599 (1989).
Capraro, H. G. and A. Brossi, "The Alkaloids," A. Brossi, editor, vol. XXIII, Academic Press, pp. 1-70 (1984).
Medrano, F. J., et al., "Roles of Ring C Oxygens in the Binding of Colchicine to Tubulin," Biochemistry, 30:3770-3777 (1991).
Andreu, J. M. and Timasheff, S. N., "Interaction of Tubulin with Single Ring Analogues of Colchicine," Biochemistry, 21:534-543 (1982).
Timasheff, S. N., et al., "Physical and Spectroscopic Methods for the Evaluation of the Interaction of Antimitotic Agents with Tubulin," Pharm. Ther., 52:191-210 (1981).
Andreu, J. M. and Timasheff, S. M., "Conformational States of Tubulin Liganded to Colchicine, Tropolone Methyl Ether and Podophyllotoxin," Biochemistry, 21:6465 (1982).

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