Allergy vaccines and their preparation

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S002600, C514S008100, C530S324000, C530S868000, C424S810000

Reexamination Certificate

active

10026911

ABSTRACT:
The present invention relates to a pharmaceutical composition containing a peptide and a pharmaceutically acceptable carrier or diluent wherein the peptide has a length of 8 to 50 amino acids, at least three preferably consecutive amino acids of the peptide are identical to at least three amino acids which appear in close vicinity on the molecular surface of an allergenic protein, and said at least three amino acids are solvent-exposed amino acids in the allergenic protein. The invention also concerns a method for the preparation of the pharmaceutical composition.

REFERENCES:
patent: 6878376 (2005-04-01), Spertini
patent: 0 714 662 (1994-07-01), None
patent: WO 96/27005 (1996-03-01), None
patent: WO 97/05258 (1996-08-01), None
patent: WO 97/24139 (1996-09-01), None
Friedl-Hajek et al., Clinical and experimental Allergy, 1999, vol. 29, pp. 478-487.
Ferreira et a., FASEB Journal, vol. 12, pp. 231-242, 1998.
Friedl-Hajek et al., Molecular Immunology, 1999, 36:639-645.
Swoboda et al. J. Biol. Chem. 1995, 270:2607-2613.
Colman, P.M., Research in Immunology, 1994, 145:33-36.
Vik et al., Int Arch Allergy Immunol, 1993, 101:89-94.
Mandler et al., J. Immunol. 1993, 150:407-418.
Harlow et al. , Antibodies, A Laboratory Manual, 1988, Cold Spring Harbor Laboratory, pp. 72-87.
Blumenthal et al. in Allergens and Allergen Immunotherapy, 3rd edition, 2004, pp. 37-50.
Denépoux, S. et al., “Molecular characterization of human IgG monoclonal antibodies specific for the major birch pollen allergen Bet v 1. Anti-allergen IgG can enhance the anaphylactic reaction,”FEBS Letters,465: 39-46 (2000).
Gajhede, M. et al., “X-ray and NMR structure of Betv1, the origin of birch pollen allergy,”Nature Structural Biology,3(12): 1040-45 (Dec. 1996).
Niederberger, V. et al., “IgE antibodies to recombinant pollen allerens (Phl p 1, Phl p 2, Phl p 5, and Bet v 2) account for a high percentage of grass pollen-specific IgE,”J. Allergy Clin. Immunol.,101: 258-264 (Feb. 1998).
Valent, P. et al., “Interleukin 3 activates human blood basophils via high-affinity binding sites,”Proc. Natl. Acad. Sci. USA, 86: 5542-46 (Jul. 1989).
Vrtala, S. et al., “Conversion of the Major Birch Pollen Allergen, Bet v 1, into Two Nonanaphylactic T Cell Epitope-containing Fragments,” J. Clin, Invest., 99(7): 1673-81 (Apr. 1997).
Vrtala, S. et al., “Properties of Tree and Grass Pollen Allergens: Reinvestigation of the Linkage between Solubility and Allergenicity,”Int. Arch. Allergy Immunol.102; 160-69 (1993).
European Search Report, EP 00 12 8659.
M. Focke et al.; “Nonallergenic Peptides from Surface-Exposed Areas or B-Cell Epitopes of Allergens for Specific Immunotherapy”,Int. Arch Allergy Immunol,124: 398-399 (2001).
E. Ganglberger et al.; “IgE Mimotopes of Birch Pollen Allergen Bet v. 1 Induce Blocking IgG in Mice”,Int. Arch Allergy Immunol,124: 395-397 (2001).
R. Furmonaviciene et al.; “The Use of Phage-Peptide Libraries to Define the Epitope Specificity of a Mouse Monoclonal Anti-Der p 1 Antibody Representative of a Major Component of the Human Immunoglobulin E Anti-Der p 1 Response”,Clinical and Experimental Allergy,29: 1563-1571 (1991).
E. Ganglberger et al.; “Allergen Mimotopes for 3-Dimensional Epitope Search and Induction of Antibodies Inhibiting Human IgE”,FASEB Journal,14: 2177-2184 (2000).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Allergy vaccines and their preparation does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Allergy vaccines and their preparation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Allergy vaccines and their preparation will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3746565

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.