Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Allergen or component thereof
Patent
1995-06-06
1998-04-07
Chan, Christina Y.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Allergen or component thereof
530370, 530379, 514 12, 536 236, A61K 300, A61K 3578, A61K 3580, C07K 100
Patent
active
057361495
ABSTRACT:
The present invention provides a nucleic acid having a nucleotide sequence coding for Sor h I, a major allergen of Sorghum halepense, and fragments thereof. The present invention also provides purified Sor h I or at least one fragment thereof, produced in a host cell transformed with a nucleic acid sequence coding for Sor h I, or at least one fragment thereof and fragments of Sor h prepared synthetically. Sor h I and fragments thereof are useful for diagnosing, treating, and preventing allergy to Johnson grass pollen.
REFERENCES:
Hoyne et al., Immunology and Cell Biology, 74: 180-186, Feb. 1996.
Becker et al., Prog. Allergy Clin. Immuno., Section IX, 220-225, Mar. 1995.
French (1930) "Pollens Which Cause Hay Fever in South Central Texas" J. Allergy 1: 286-291;.
L.o slashed.wenstein et al. (1992) "Immunoelectrophoretic Analyses of the Allergens in Paspalum-Notatum Bahia Grass and Sorghum-Halepense Johnson Grass Polens" J. Allergy Clin. Immunol. 89(1 Part 2): 151;.
Martin et al. (1985) "Cross-Allergenicity Among the Grasses" Annals of Aller. 54: 99-104;.
Matthieson et al. (1991) "Characterization of the major allergen of Cynodon dactylon (Bermuda grass) pollen, Cyn d l." J. Allergy Clin. Immunol. 88: 763-774;.
Ruffin et al. (1983) "A Physiological Characterization of Allergenic Pollen-Held Proteins" Environmental and Experimental Botany. 23(4): 311-319;.
Watson et al. (1992) "Etiology of Hay Fever in Arizona and the Southwest" JAMA 78: 718-722;.
Avjioglu Asil
Knox Robert Bruce
Singh Mohan Bir
Chan Christina Y.
Mandragouras Amy E.
Nolan Patrick T.
Remillard Jane E.
The University of Melbourne
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