Allergenic compositions

Details Allergenic compositions Allergenic compositions

1982-06-28

1985-11-12

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

424 91, A61K 3900

Patent

active

045527563

ABSTRACT:
Improvement in the preparation of allergens, for the obtention of more stable and more effective preparations from extracts of various materials such as pollens, house dust, kapok, wool, molds, etc. extracts containing only allergenic substances having molecular weights in the range of from about 10,000 and 50,000 and being free from enzymes are broadly contemplated.
The substances have no allergenic activity are removed from the aqueous extract. In particular, molecular masses below 14,000 and above 45,000 are eliminated.
The allergen thus improved is suitable in the adsorbed form, for example, on alumina and phosphates of aluminum or of calcium; it provides particularly good results when the adsorbent is a special phosphate in which the ponderal ratio Ca/P is 1.55 to 1.90.

REFERENCES:
Rose et al-Condensed Chemical Dictionary, 7th edit. (Reinhold Pub., N.Y.) p. 372.
King et al-Biochemistry, vol. 3, No. 3 (Mar. 1964) pp. 458-463.
King et al-Biochemistry, vol. 1, No. 4 (Jul. 1962) pp. 709-720.
Johnson et al-Chem. Abst., vol. 63 (1965) p. 10487b.
Kabasawa et al-Chem. Abst. vol. 90 (1979) p. 202,058u.
Smart et al-Chem. Abst., vol. 93 (1980) pp. 24,105j.
Smart et al-Int. Arch. Allergy Appl. Immunol., vol. 62 (1980) pp. 179-187.

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