Allergen/inflammatory testing and diagnosis

Details Allergen/inflammatory testing and diagnosis Allergen/inflammatory testing and diagnosis

2005-09-20

2005-09-20

Schwadron, Ronald B. (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving viable micro-organism

C435S002000, C435S007100, C435S007200, C435S007240, C435S325000, C435S372000, C435S353000, C435S355000, C436S169000, C436S804000, C436S811000

Reexamination Certificate

active

06946260

ABSTRACT:
The invention relates to the use of a secretor variant cell-line expressing the alpha moiety of human IgE binding protein to determine the allergic status of a given individual. Moreover, the cell-line is also used to provide an assay system for determining the allergenicity of substances and for subsequently providing therapeutic compositions which render said substances ineffective. In addition, the invention also relates to the use of said cell-line to determine the IgE independent irritancy of substances and compositions effective for attenuating the effects of said substances.

REFERENCES:
patent: 4559310 (1985-12-01), Cantor et al.
Wilson et al., J. clin. Immunoassay, 16:91-95, 1993.
Levi-Schaffer et al., Pharmacol. Res., 24:307-317, 1991.
Gilfillan et al., J. Immunol., 149:2445-2451, 1992.
Benyon et al., Br. J. Pharmacol., 97:898-904, 1989.
Komisar et al., Inf. and Immunity, 60:2961-72, 1992.
Bochner et al., New England J. Med., 324: 1785-1790, 1991.

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