Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-02-08
1989-07-11
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514445, 514446, 514448, 549 65, 549 72, 549 71, 549 74, 549 64, A61K 3138, C07D 3336, C07D 3346
Patent
active
048472883
ABSTRACT:
The present invention relates to compounds which are allenyl amines, more specifically, .beta.-ethenylidene-(substituted)ethanamines, possessing antihypertensive activity. They are prepared by a noval reaction of a protected N,N-bis(trimethylsilyl)-4-methoxy-2-butynylamine compound with a metallo-organic compound, with subsequent removal of the silyl protecting groups to provide the desired compound.
REFERENCES:
patent: 4788301 (1988-11-01), Bargar et al.
Bargar Thomas M.
Barney Charlotte L.
Broersma Robert J.
Matthews Donald P.
McCarthy James R.
Brewer Alice A.
Lee Mary C.
Magrab E. Brendan
Merrell Dow Pharmaceuticals Inc.
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