Allelic variation of the serotonin 5HT7 receptor

Details Allelic variation of the serotonin 5HT7 receptor Allelic variation of the serotonin 5HT7 receptor

1996-11-08

1998-06-09

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 435 4, 4353201, 4352402, 4352523, 4352404, 43525411, 4352549, 530350, 2041828, 536 231, 536 243, 536 2432, C12Q 168, C12P 1934, C07H 2102, C07H 2104

Patent

active

057631832

ABSTRACT:
An allelic variant of the 5HT7 serotonin receptor was discovered. Family study data indicate that this variant can be correlated to alchoholic offerders. DNA encoding the variant protein, the protein itself, vectors containing the variant gene and cell lines carrying a vector with the variant gene are part of the invention.

REFERENCES:
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Bard et al. Genbank Sequence Listing, Accession No. L 21195, 1993.
U. Pesonen, et al., Rare non-conservative amino acid substitution in the 5-HT.sub.7 receptor gene found in alcoholics with antisocial personaltiy disorder, Soc. Neurosci, Abstr., 21, p. 1121, 1995.
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Roth B.L., et al. J. Pharmacol. Exp. Ther. 268:1403, 1994.
Linnoila, et al., J. Clin Psychiatry 53:10 (suppl), 1992.
Lappalainen, et al., Genomics 27, 274-279, 1995.

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