Allelic variation of the serotonin 5HT.sub.2c receptor

Details Allelic variation of the serotonin 5HT.sub.2c receptor Allelic variation of the serotonin 5HT.sub.2c receptor

1994-09-21

1997-08-05

Allen, Marianne P.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 235, 536 243, 536 2431, 536 2433, 4353201, 435334, C12N 1500, C12N 1512

Patent

active

056541392

ABSTRACT:
We describe identification of a non-conservative amino acid substitution in the 5-HT.sub.2C receptor gene. The variant was found using single strand conformational polymorphism (SSCP) analysis. By typing this polymorphism in CEPH families, the gene was genetically mapped on the long arm of the X chromosome. Since this polymorphism was not detectable as a conventional RFLP, we also developed a PCR-RFLP based method which allows rapid genotyping in populations and families.

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