Allelic diagnosis of susceptibility to compulsive disorder

Details Allelic diagnosis of susceptibility to compulsive disorder Allelic diagnosis of susceptibility to compulsive disorder

1994-09-01

1996-08-27

Jones, Gary W.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 435810, 536 231, 536 235, 536 2431, 536 2433, 935 76, 935 77, 935 78, C12Q 168, C12P 1934, C07H 2104, C12N 1500

Patent

active

055500218

ABSTRACT:
In an important embodiment, the present invention concerns a method for diagnosing and detecting compulsive disorder susceptibility of an individual. The method comprises initially obtaining a DNA sample of said individual and then determining the presence or absence of particular human D.sub.2 receptor gene alleles in said sample. Detection of said alleles in the sample are indicative of predilection to compulsive disorder. A most preferred embodiment is to detect predisposition to impulsive, addictive, and compulsive disorders such as, but not limited to, alcoholism, obesity, smoking, polysubstance abuse and drug addiction, particularly because said alleles have been found to be present in a majority of individuals clinically diagnosed with these compulsive disorders. The human D.sub.2 receptor gene A1, B1, and .sup.In6-Ex7 haplotype I alleles are most preferably detected in said sample.

REFERENCES:
patent: 5210016 (1993-05-01), Blum et al.
Sequence Comparison; Registry File; RN 151632-04-1
Suarez et al., Genomics 19: 12-20 (1994).
Holden etal., Science, vol. 264, pp. 1696-1697, Jun. 1994.

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