Allelic association of the human dopamine(D2) receptor gene in c

Details Allelic association of the human dopamine(D2) receptor gene in c Allelic association of the human dopamine(D2) receptor gene in c

1992-06-24

1996-03-19

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 435 912, 435810, 536 231, 536 235, 536 2433, 935 31, 935 78, C12Q 168, C12P 1934, C07H 2104, C12N 1500

Patent

active

055003435

ABSTRACT:
In an important embodiment, the present invention concerns a method for detecting compulsive disorder susceptibility of a human. The method comprises initially obtaining a DNA sample of said human and then determining the presence or absence of a particular human D.sub.2 receptor gene allele in said sample. Detection of said allele in the sample is indicative of susceptibility to compulsive disorder. A most preferred embodiment is to detect a susceptibility to alcoholism and cocaine dependence, particularly because said allele has been found to be present in a majority of clinically diagnosed alcoholics and cocaine users. The human D.sub.2 receptor gene A1 and B1 alleles are most preferably detected in said sample.

REFERENCES:
patent: 5210016 (1993-05-01), Blum et al.
Suarez et al., Genomics vol. 19, pp. 12-20 (1994).
Holden, Science, vol. 264, pp. 1696-1697, 17 Jun. 1994.

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