Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1992-01-23
1993-05-11
Moskowitz, Margaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
436501, C12Q 168, G01N 33566
Patent
active
052100162
ABSTRACT:
In an important embodiment, the present invention concerns a method for diagnosing compulsive disease predisposition of an individual. The method comprises initially obtaining a DNA sample of said individual and then determining the presence or absence of a particular human D.sub.2 receptor gene allele in said sample. Detection of said allele in the sample is indicative of predilection to compulsive disease. A most preferred embodiment is to detect predisposition to alcoholism, particularly because said allele has been found to be present in a majority of clinically diagnosed alcoholics. The human D.sub.2 receptor gene A1 allele is most preferably detected in said sample.
REFERENCES:
patent: 4761429 (1988-08-01), Blum et al.
Byerley et al. "Molecular Genetic Studies Using D.sub.2 Dopamine Receptor", May 1989.
Search Report for International Patent Application No. PCT/US91/00855, mailed Jul. 29, 1991.
Blum et al., "Allelic Association of Human Dopamine D.sub.2 Receptor Gene in Alcoholism", J. Am. Med. Assoc., 263(15): 2055-2060, Apr. 18, 1990.
Grandy, et al., "The human dopamine D.sub.2 receptor gene is located on chromosome II at q22-q23 and identifies a TaqI RFLP", Am. J. Human Genetics, 45(5):778-785, Nov. 1989.
Bolos et al., "Population and pedigree studies reveal a lack of association between the dopamine D.sub.2 receptor gene and alcoholism", J. Am. Med. Assoc., 264(24):3156-60, Dec. 26, 1990.
Blum Kenneth
Noble E. P.
Sheridan P. J.
Board of Regents , The University of Texas System
Moskowitz Margaret
Regents of the University of California
Sisson Bradley L.
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