Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-07-04
2006-07-04
Switzer, Juliet C (Department: 1634)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S320100, C435S252300, C435S455000, C435S471000, C435S325000, C536S023500
Reexamination Certificate
active
07071315
ABSTRACT:
Provided herein are variant alleles of a gene encoding a mu opioid receptor, along with cloning vectors for replicating such variant alleles, expressing vectors for expressing the variant alleles to produce variant mu opioid receptors, and antibodies to such variant receptors. Also disclosed are binding characteristics of such variant receptors regarding binding to opioid ligands, and the using of such binding characteristics to diagnose a subjects susceptibility to pain, susceptibility to an addictive disease, selecting an appropriate pain reliever along with a therapeutically effective amount of the reliever to administer to a subject suffering from pain. In addition, diagnostic methods for diagnosing a disease or disorder such as infertility, constipation, diarrhea, decreased immune response relative to a standard, and decreased ability to withstand stress relative to a standard, along with commercial kits for diagnosing such diseases or disorders. Furthermore, the invention is also directed to identification of targeted prevention methods, early therapeutic intervention, and improved treatment of opioid addiction, infertility, constipation, diarrhea, impaired immune responsiveness, and stress.
REFERENCES:
patent: 5474796 (1995-12-01), Brennan
patent: WO 95/07983 (1995-03-01), None
Bond et al. (PNAS USA, vol. 95, p. 9608-9613, Aug. 1998).
Ahern (The Scientist, vol. 9, No. 15, p. 20, Jul. 1995; computer print out provided, page numbers refer to the print out).
Berrettini, Wade H. et al. Addiction Biology vol. 2: pp. 303-308 (1997).
Wang, J.B., et al. GenBank Accession No. L25119, Aug. 8, 1994.
Bare, L.A., et al. GenBank Accession No. U12569, Apr. 12, 1995.
Kreek Mary Jeanne
LaForge Karl Steven
Klauber & Jackson
Switzer Juliet C
The Rockefeller University
LandOfFree
Alleles of the human mu opioid receptor, diagnostic methods... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Alleles of the human mu opioid receptor, diagnostic methods..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alleles of the human mu opioid receptor, diagnostic methods... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3599638