Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 15 to 23 amino acid residues in defined sequence
Patent
1989-12-18
1991-08-13
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
15 to 23 amino acid residues in defined sequence
530328, 530858, C07K 706, C07K 708
Patent
active
050397923
ABSTRACT:
An eighteen amino acid neuropeptide isolated from brain complexes of adult female cockroach, Diploptera punctata, is identified as an allatostatin because it inhibits the biosynthesis of juvenile growth hormone in cockroach corpora allata. Primary structure of the isolated allatostatin is Al a-Tyr-Ser-Tyr-Val-Ser-Glu-Tyr-Lys-Arg-Leu-Pro-Val-Tyr-Asn-Phe-Gly-Leu-NH.s ub.2. A synthetic peptide of this sequence and three synthetic peptides with truncated sequences conserving the amidated carboxyl portion of the native sequence have allatostatin activity. Certain derivatives of the peptides also have allatostatin activity including compounds having the sequence: X-Val-Tyr-Asn-Phe-Gly-Leu-NH.sub.2, in which X is Leu-Arg, Leu-Pro, Arg-Leu-Pro-, Ala-Tyr-Ser-Tyr-Val-Ser-Glu-Tyr-Lys-Arg-Leu-Pro, acetyl-Ala-Tyr-Ser-Tyr-Val-Ser-Glu-Tyr-Lys-Arg-Leu-Pro, or acetyl-Arg-Leu-Pro. These peptides have the potential for regulating the growth of certain insects, and may be useful in the area of insect control.
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Farnsworth Dan E.
Feyereisen Rene
Fok Kam F.
Pratt Grahame E.
Siegel Ned R.
Monsanto Company
Oregon State University
Russel Jeffrey E.
Walsh Stephen
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