All-trans retinaldehyde binding protein, DNA encoding same, and

Details All-trans retinaldehyde binding protein, DNA encoding same, and All-trans retinaldehyde binding protein, DNA encoding same, and

1998-06-05

1999-12-28

Kemmerer, Elizabeth

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 293, 435 6, 4353201, 435325, 4352533, 435 691, 530300, 530350, C07N 2106, C12N 1512, C12N 1513

Patent

active

060083387

ABSTRACT:
An isolated DNA molecule encodes a photoreceptive retinaldehyde-binding protein of the visual system and brain. The isolated protein is a putative receptor for an all-trans-retinylidene chromophore that absorbs light in the visible range. Antibodies are disclosed which specifically bind to such retinaldehyde binding protein. An altered retinaldehyde binding protein with a 38 amino acid deletion is an indicator of abnormality in the retinal pigment epithelium. Antibodies are also disclosed which are specific to the altered retinaldehyde binding protein.

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