All-trans retinaldehyde binding protein, and antibodies thereto

Details All-trans retinaldehyde binding protein, and antibodies thereto All-trans retinaldehyde binding protein, and antibodies thereto

1994-12-16

1998-06-09

Walsh, Stephen

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

530395, 53038822, 5303891, 930 10, C07K 14705, C07K 1628

Patent

active

057635781

ABSTRACT:
An isolated DNA molecule encodes a photoreceptive retinaldehyde-binding protein of the visual system and brain. The isolated protein is a putative receptor for an all-trans-retinylidene chromophore that absorbs light in the visible range. Antibodies are disclosed which specifically bind to such retinaldehyde binding protein. An altered retinaldehyde binding protein with a 38 amino acid deletion is an indicator of abnormality in the retinal pigment epithelium. Antibodies are also disclosed which are specific to the altered retinaldehyde binding protein.

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