Radiant energy – Ionic separation or analysis – Static field-type ion path-bending selecting means
Reexamination Certificate
2004-05-28
2008-07-15
Vanore, David A. (Department: 2881)
Radiant energy
Ionic separation or analysis
Static field-type ion path-bending selecting means
C250S282000
Reexamination Certificate
active
07399962
ABSTRACT:
A method of obtaining a mass spectrum of elements in a sample is disclosed. Sample precursor ions having a mass to charge ratio M/Z are generated, and fragmented at a dissociation site, so as to produce fragment ions of mass to charge ratio m/z. The fragment ions are guided into an ion trap of the electrostatic or “Orbitrap” type, the fragment ions entering the trap in groups dependent upon the precursor ions M/Z. The mass to charge ratio of each group is determined from the axial movement of ions in the trap. The electric field in the trap is distorted. Ions of the same m/z, that are derived from different pre-cursor ions, are then separated, because the electric field distortion causes the axial movement to become dependent upon factors other than m/z alone.
REFERENCES:
patent: 5734162 (1998-03-01), Dowell
patent: 6759652 (2004-07-01), Yoshinari et al.
patent: 6977373 (2005-12-01), Yoshinari et al.
patent: 7166835 (2007-01-01), Baba et al.
patent: 7208728 (2007-04-01), Hashimoto et al.
patent: 7227137 (2007-06-01), Londry et al.
patent: 7288761 (2007-10-01), Collings
patent: 2 378 312 (2003-02-01), None
Hardman et al., “Interfacing the Orbitrap Mass Analyzer to an Electrospray Ion Source,” Analytical Chemistry, vol. 75, ( No. 7), p. 1699-1705, (Apr. 1, 2003).
Hoaglund-Hyzer et al., “Mobility Labeling for Parallel CID of Ion Mixtures,” Analytical Chemistry, vol. 72 ( No. 13), p. 2737-2740, (Jul. 1, 2000).
Marshall et al., “Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry/Mass Spectrometry with Stored-Waveform Ion Radius Modulation,” J. Am. Chem. Soc., vol. 115 ( No. 17), p. 7854-7861, (Aug. 25, 1993).
Katz Charles B.
Thermo Finnigan LLC
Vanore David A.
LandOfFree
All-mass MS/MS method and apparatus does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with All-mass MS/MS method and apparatus, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and All-mass MS/MS method and apparatus will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3963739