Alkyne compounds and method of use

Details Alkyne compounds and method of use Alkyne compounds and method of use

1976-06-18

1978-09-19

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424341, 424345, 560100, 560107, 560255, 568807, 568809, C07C 4320

Patent

active

041154568

ABSTRACT:
Alkyne compounds of the formula ##STR1## wherein R.sup.1 is H, alkyl of up to 4 carbon atoms or phenyl; R.sup.2 is H, aliphatic acyl of up to 6 carbon atoms or aroyl of up to 11 carbon atoms; R.sup.3 and R.sup.4 are H, F, Cl or Br and n is 0 or 1, and physiologicaly acceptable metals salts thereof, have antiinflammatory activity. These compounds can be made from compounds of the formula ##STR2## wherein Q is a functionally-modified hydroxy and R.sup.1, R.sup.3, R.sup.4 and n are as above by treatment with a solvolyzing agent.

REFERENCES:
patent: 3879449 (1975-04-01), Anderson et al.

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