Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-06-28
1980-04-01
Myers, Jane S.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
560100, 560107, 560255, 424311, A61K 3122, A61K 31235, C07C 6978, C07C 6902
Patent
active
041962150
ABSTRACT:
Alkyne compounds of the formula ##STR1## wherein R.sup.1 is H, alkyl of up to 4 carbon atoms or phenyl; R.sup.2 is H, aliphatic acyl of up to 6 carbon atoms or aroyl of up to 11 carbon atoms; R.sup.3 and R.sup.4 are H, F, Cl or Br and n is 0 or 1, and physiologically acceptable metals salts thereof, have anti-inflammatory activity. These compounds can be made from compounds of the formula ##STR2## wherein Q is a functionally-modified hydroxy and R.sup.1, R.sup.3, R.sup.4 and n are as above by treatment with a solvolyzing agent.
REFERENCES:
patent: 3890377 (1975-06-01), Marshall
patent: 4049823 (1977-09-01), Schacht et al.
Chem. Abstracts, 65, 18528 (1966).
Gante Joachim
Kurmeier Hans-Adolf
Orth Dieter
Schacht Erich
Wild Albrecht
Merck Patent Gesellschaft mit beschraenkter Haftung
Myers Jane S.
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