Alkylthiophenoxypropanolamines and pharmaceutical compositions a

Details Alkylthiophenoxypropanolamines and pharmaceutical compositions a Alkylthiophenoxypropanolamines and pharmaceutical compositions a

1979-04-16

1981-01-06

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

26050117, 564349, A61K 31135, C07C 8300, C07C 9100, C07C 9306

Patent

active

042436818

ABSTRACT:
A new class of alkylthiophenoxypropanolamine derivatives and methods for preparation are described. The compounds have vasodilating and antispasmodic activity, inhibit blood platelet aggregation and are substantially free of beta-adrenergic blocking effects. They are particularly valuable in the treatment of disease states responsive to vasodilation such as obstructive peripheral vascular diseases and cerebral vascular deficiencies. A representative and preferred embodiment of the invention consists of 1-[4-(1-methylethylthio)phenoxy]-3-(octylamino)-2-propanol.

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patent: 3542874 (1970-11-01), Keizer et al.
patent: 3631108 (1971-12-01), Brandstrom et al.
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patent: 3872147 (1975-03-01), Koppe et al.
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patent: 3928601 (1975-12-01), Brandstrom et al.
patent: 3930016 (1975-12-01), Berntsson et al.
patent: 3937834 (1976-02-01), Hanger et al.
patent: 4067904 (1978-01-01), Comer et al.
patent: 4084002 (1978-04-01), Koppe et al.
J. of Med. Chem., 13, (5), 971-973, (1970), Boissier.

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