Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-07-28
1979-04-03
Meyers, Albert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
2605707, A61K 31135, C07C 9306
Patent
active
041478053
ABSTRACT:
A new class of alkylthiophenoxyalkylamine derivatives and methods for preparation are described. The compounds have vasodilating and antispasmodic activity, inhibit blood platelet aggregation and are substantially free of beta-adrenergic blocking effects. They are particularly valuable in the treatment of disease states responsive to vasodilation such as obstructive peripheral vascular diseases and cerebral vascular deficiencies. Representative and preferred embodiments of the invention are N-[3-[4-(methylthio)phenoxy]propyl]octylamine and N-[3-[4-(1-methylethyl)thio]phenoxy]-propyl]octylamine.
REFERENCES:
patent: 3746768 (1973-07-01), Bordenca et al.
patent: 3808257 (1974-04-01), Richtner et al.
patent: 3873620 (1975-03-01), Pinhas
patent: 3930016 (1975-12-01), Berntsson et al.
Med. Chem. 2nd ed., p. 600--Interscience, N.Y.--A. Burger.
Carnahan Robert E.
Mead Johnson & Company
Meyers Albert T.
Robinson D. W.
Uloth Robert H.
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