Alkylthio alkyl avermectins are active antiparasitic agents

Details Alkylthio alkyl avermectins are active antiparasitic agents Alkylthio alkyl avermectins are active antiparasitic agents

1992-03-24

1993-07-20

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514 30, 536 71, 549264, 549265, A61K 31365, C07D49322

Patent

active

052294153

ABSTRACT:
Avermectin compounds are substituted at the 4", 4' or 13-postion hydroxy group with an alkylthioalkyl group and are optionally substituted at the other reactive positions of the avermectin molecule. The compounds are prepared by reacting protected avermectins, avermectin monosaccharides or avermectin aglycones with dialkylsulfoxides. The compounds are potent antiparasitic agents and compositions for such uses are also disclosed.

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