Alkylsulfonylphenoxypropanolamine derivatives

Details Alkylsulfonylphenoxypropanolamine derivatives Alkylsulfonylphenoxypropanolamine derivatives

1976-09-10

1978-01-10

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2603405R, 2603437, 26050117, 26050118, 26050119, 424280, 424282, 424316, 424330, C07C 9306

Patent

active

040679047

ABSTRACT:
A new class of phenoxypropanolamine alkylsulfonyl derivatives and methods for their preparation are described. The new compounds possess antiarrhythmic and/or cardioselective .beta.-adrenergic blocking properties and are useful in the treatment of hypertension. Representative embodiments of the invention are 1-(isopropylamino)-3-[4-(methylsulfonyl)-m-tolyloxy]-2-propanol and 3-[4-(methylsulfonyl)-m-tolyloxy]-1-(1-phenoxy-2-propylamino)-2-propanol, the latter compound is particularly outstanding as an antihypertensive.

REFERENCES:
patent: 3375256 (1968-03-01), Bach et al.
patent: 3501769 (1970-03-01), Crowther et al.
patent: 3627832 (1971-12-01), Schulenberg et al.
patent: 3631108 (1971-12-01), Brandstrom et al.
patent: 3732308 (1973-05-01), Lauria et al.
Dearwent Abstracts, "Basic No. 41,107", pp. 357-366 (1969).
Burger, "Medicinal Chemistry", Third Ed., p. 77 (1970).

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