Alkylpolyglycoside and pyrimidine derivative based composition f

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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424 701, 514 25, 514 70, 514781, 514880, 514881, 514888, A61K 31505, A61K 706, A61K 3170

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active

055677010

ABSTRACT:
A composition for inducing and stimulating hair growth and/or reducing hair loss comprises at least one alkylpolyglycoside and at least one compound having formula (I) in a physiologically acceptable medium. ##STR1## In compound (I) , R.sub.1 represents the group ##STR2## where in R.sub.3 and R.sub.4 may be selected from hydrogen, alkyl, alkenyl or cycloalkyl. R.sub.3 and R.sub.4 may also form a heterocycle with the nitrogen atom to which they are bonded. The heterocycle may be an aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, hexahydroazepinyl, heptamethyleneimine, octamethyleneimine, morpholine or 4-low alkylpiperazidinyl group. These heterocycles may be substituted at the carbon atoms by one to three alkyl, hydroxy or alkoxy groups. R.sub.2 is selected from hydrogen, alkyl, alkenyl, alkylalkoxy, cycloalkyl, aryl, alkylaryl, arylalkyl, alkylarylalkyl, alkoxyarylalkyl and/or haloarylalkyl. The physiologically acceptable acid addition salts of the compound may also be used.

REFERENCES:
patent: 4765976 (1988-08-01), Grollier et al.
patent: 4820512 (1989-04-01), Grollier
patent: 4871839 (1989-10-01), Gibson
MacKenzie 1962, A New Dictionary of Chemistry, 240 and 241 and 244.

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