Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1997-04-18
1999-12-21
Ramsuer, Robert W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514651, 544155, 546204, 548528, 564322, 564352, A61K 3140, A61K 31535, C07D295116
Patent
active
060049596
ABSTRACT:
The present invention describes certain alkyloxyamino-substituted fluorenones which inhibit protein kinase C, as well as pharmaceutical compositions including these compounds and methods of using these compounds to control protein kinase C activity in mammals, including humans. More specifically, the present compounds are useful for the treatment of neoplastic disease states, disorders associated with abnormal blood flow (including hypertension, ischemia, atherosclerosis, coagulation disorders), and inflammatory diseases (including immune disorders, asthma, lung fibrosis, and psoriasis).
REFERENCES:
patent: 3592819 (1971-07-01), Fleming et al.
patent: 3671587 (1972-06-01), Trexler et al.
patent: 3814770 (1974-06-01), Andrews et al.
patent: 4064347 (1977-12-01), Fleming et al.
patent: 4816450 (1989-03-01), Bell et al.
patent: 5189046 (1993-02-01), Burch et al.
patent: 5340931 (1994-08-01), Yamada et al.
patent: 5459262 (1995-10-01), Schmitz
patent: 5514719 (1996-05-01), LaTorse et al.
Fu et al, J. Org. Chem., 56, pp. 1683-1685 (1991).
de Silva et al, Tetrahedron, vol. 48, No. 23, pp. 4863-4878 (1992).
Ladd, D., et al, J. Med. Chem. 29, pp. 1904-1912 (1986).
Sill, A., et al, J. Medicinal Chem., vol. 16, No. 3, pp. 240-245 (1973).
Miller, M., et al, J. Am. Chem. Soc., 102, pp. 7026-7032 (1980).
Bradshaw, D., et al, Agents Actions 38, pp. 135-147 (1993).
Davis, P., et al, FEBS Letters, vol. 259, No. 1, pp. 6-63 (1989).
Chemical Abstracts, vol. 62 (1965).
Chemical Abstracts, vol. 65 (1966).
Sala, T. et al, J. Chem. Soc. Perkin Trans. I, pp. 2593-2598 (1979).
Andrews, E.R., et al, J. Medicinal Chem. vol. 17, No. 8, pp. 882-886 (1974).
Sargent, M.V., J. Chem. Soc. Perkin Trans., 1, pp. 2553-2563 (1987).
Fu, J.-M., et al, Can. J. Chem., vol. 72, pp. 227-236 (1994).
Wang, W. et al, J. Org. Chem., 57, pp. 424-426 (1992).
Meyers, A., et al, J. Org. Chem., vol. 39, No. 18, pp. 2787-2793 (1974).
Meyers, A., et al, J. Am. Chem. Soc. Comm., 97:25, pp. 7383-7385 (1975).
Morgan, G., et al, J. Chem. Soc. Perkin Trans. I, pp. 2691-2696 (1926).
Mohindra, H., et al, Indian J. of Chem., vol. 26B, pp. 992-993, (Oct. 1987).
Gant, T., et al, Tetrahedron, vol. 30, No. 8, pp. 2297-2360 (1994).
Reuman, M., et al, Tetrahedron, vol. 40, No. 5, pp. 837-860 (1985).
Hannun, Y., et al, J. of Biological Chem., vol. 262, No. 28, pp. 13620-13626, (Oct. 5, 1987).
Wilson, E., et al, J. of Biological Chem., vol 261, No. 27, pp. 12616-12623 (Sep. 25, 1986).
Castagna, M., et al, J. of Biological Chem., vol. 262, No. 13, pp. 7847-7851, (Jul. 10, 1982).
Pittet, D. et al, J. Biological Chem.,vol. 262, pp. 10072-10076 (Jul. 25, 1987).
Fujita, I., et al, Biochemical Pharmacology, vol. 35, No. 24, pp. 4555-4562 (1886).
Gaudry, M., et al, Immunology, 63, pp. 715-719 (1988).
Yamada, K., et al, Biochemical Pharmacology, vol. 37, No. 6, pp. 1161-1166 (1988).
Berkow, R., et al, J. of Leukocyte Biology, 41, pp. 441-446 (1987).
Schachtele, C., et al, Biochemical and Biophysical Research Comm., vol. 151, No. 1, pp. 542-547 (Jan. 29, 1988).
Salzer, W., et al, Biochem. Biophys. Res. Comm., vol. 148, No. 2, pp. 747-754 (Oct. 29, 1987).
Dewald, B., et al, Biochem. J., 264, pp. 879-884 (1989).
Kramer, I., et al, J. Biological Chem., vol. 264, No. 8, pp. 3818-3822 (Mar. 15, 1988).
Lambeth, J., et al, J. of Biological Chem., vol. 263, No. 8, pp. 3818-3822 (Mar. 15, 1988).
McIntyre, T., et al, J. Biological Chem., vol. 262, No. 32, pp. 15370-15376 (Nov. 15, 1987).
Dodd, J., Synthetic Communications, 23(7), pp. 1003-1008 (1993).
Barker, A., et al, J. Chem. Soc. 870 (1954).
Colste, J. et al, Tetrahedron Letters, vol. 31, No. 2, pp. 205-208 (1990).
Martinez, J. et al, J. Med. Chem., 28, pp. 1874-1879 (1985).
Frerot E., et al, Tetrahedron Letters, vol. 47, No. 2, pp. 259-270 (1991).
Hoeg-Jensen, T. et al, Tetrahedron Letters, vol. 32, No. 51, pp. 7617-7620 (1991).
Calbiochem-Novabiochem. Corp. Catalog pp. 162-165.
Jones, Winton et al, J. Org. Chem., vol. 61, No. 11, pp. 3920-3922.
Ciske Fred L.
Diekema Keith A.
Dinerstein Robert J.
Jones Winton D.
Hoechst Marion Roussel Inc.
Payne T. Helen
Ramsuer Robert W.
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