Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrol

Details Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrol Alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrol

1990-10-11

1991-11-26

Scalzo, Catherine S. Kilby

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47110

Patent

active

050683322

ABSTRACT:
This invention relates to alkylidene analogs of 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones, represented by formula (I): ##STR1## to processes for the preparation, to methods for using the compounds, and to pharmaceutical preparations thereof. The compounds have pharmaceutical properties which render them beneficial for the prevention or treatment of diabetes mellitus associated complications.

REFERENCES:
patent: 4575507 (1986-03-01), Lipinski
patent: 4927831 (1989-09-01), Malamas
McCaleb et al., J. Diabetes, Comp. 2, 16, 1989.
Robinson et al., Invest. Ophthalmol. Vis. Sci., 30, 2285, 1989.
Notvest & Iserra, Diabetes, 36, 500, 1987.

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