Alkylative cleavage of azetidinone disulfides

Details Alkylative cleavage of azetidinone disulfides Alkylative cleavage of azetidinone disulfides

1976-09-22

1979-11-13

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602452, 2602454, 2603457R, 2603458R, C07D20508, C07D49900

Patent

active

041743180

ABSTRACT:
Novel semisynthetic 4-thio-azetidin-2-one derivatives of use in the production of cephalosporins, penicillins and related .beta.-lactam antibiotic compounds are provided by cleavage reactions involving the corresponding 4-dithio-azetidin-2-one derivative or a suitable thiazoline derivative, which starting materials may be obtained from penicillins without changing the configuration of the .beta.-lactam structure desired in the final product.

REFERENCES:
patent: 3872086 (1975-03-01), Barton et al.
patent: 3880833 (1975-04-01), Scartazzini et al.
Schonberg et al. I, Chem. Ber. 62, 440-441 (1929).
Jacobson et al., J. Amer. Chem. Soc. 77, 6064-6065 (1955).
Fromm et al., Chem. Abs. 7, 1001 (1913).
Schonberg et al. II, Chem. Ber. 66, 237-244 (1933).
Schonberg, et al. III, J. Chem. Soc. 1949, pp. 892-893.
3,993,646 11001976 Kamiya et al. 260 239 A

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