Alkylations of cyclodextrins leading to derivatives which have a

Details Alkylations of cyclodextrins leading to derivatives which have a Alkylations of cyclodextrins leading to derivatives which have a

1997-10-24

1999-08-10

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 186, 536103, 536124, A61K 31715, C08B 3716

Patent

active

059359412

ABSTRACT:
By controlling basicity of the reaction, is possible to alkylate preferentially the secondary hydroxyls of cyclodextrins. These hydroxyls surround the principal, wide, entry into the cyclodextrin cavity and, thus, their substitution by suitably chosen substituents can improve the formation of inclusion complexes. By methods of the invention, cyclodextrin derivatives substituted with fused 1,4-dioxane ring(s) can be obtained. If a reagent with one alkylating moiety is used, a mixture of ethers of cyclodextrin is formed. Using methods of this invention, up to 96% of the substitution can be directed to the secondary hydroxyls.

REFERENCES:
patent: 4764604 (1988-08-01), Muller
patent: 4870060 (1989-09-01), Muller
patent: 5096893 (1992-03-01), Pitha et al.
patent: 5710268 (1998-01-01), Wimmer
Remington, "Pharmaceutical Sciences" 15th Mack Publishing Company, Easton, PA; p. 230, 1975.
Rao et al., "Substitution in .beta.-cyclodextrin Directed by Basicity: Org. Chem., 1991, 56, pp. 1327-1329.

Affiliated with

Also associated with

Rating

Alkylations of cyclodextrins leading to derivatives which have a does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alkylations of cyclodextrins leading to derivatives which have a, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alkylations of cyclodextrins leading to derivatives which have a will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1120280