Alkylation of aniline with a lactone in the presence of water

Details Alkylation of aniline with a lactone in the presence of water Alkylation of aniline with a lactone in the presence of water

1977-11-01

1979-08-21

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

549 63, 549 62, C07D30732, C07D33336

Patent

active

041653220

ABSTRACT:
A process for producing a lactone-substituted aniline wherein an alpha-halo-gamma-butyrolactone is reacted with an aniline in the presence of water at a temperature between 80.degree. and 160.degree. C. Thus, 3-(N-2,6-dimethylphenylamino)-gamma-butyrolactone is prepared by reacting an alpha-halo-gamma-butyrolactone with 2,6-dimethylaniline in the presence of water and an inert organic solvent at a temperature between 80.degree. and 160.degree. C. This process is advantageously combined with a subsequent acylation step to provide a continuous means for making materials such as 3-(N-chloroacetyl-N-2,6-dimethylphenylamino)-gamma-butyrolactone.

REFERENCES:
patent: 2650231 (1953-08-01), Arnold
patent: 3002976 (1961-10-01), Janssen
patent: 3097206 (1963-07-01), Zirkle
patent: 3484457 (1969-12-01), Mushowski
patent: 3639385 (1972-02-01), Weaver
patent: 3933860 (1976-01-01), Chan

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