Alkylation of 3(5)-cyano-1H-pyrazole-4-carboxylic acid esters

Details Alkylation of 3(5)-cyano-1H-pyrazole-4-carboxylic acid esters Alkylation of 3(5)-cyano-1H-pyrazole-4-carboxylic acid esters

1987-04-01

1989-04-11

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23114

Patent

active

048208450

ABSTRACT:
The present invention provides a process for selectively alkylating pyrazoles comprising reacting a 3(5)-cyano-1H-pyrazole-4-carboxylic acid ester with a C.sub.4 -C.sub.8 alkene, or a C.sub.5 -C.sub.6 cycloalkene substituted at the 1-position with a C.sub.1 -C.sub.4 alkyl group, and a strong acid in a solvent which contains a strong electron withdrawing group. Also provided are new 3(5)-cyano-1H-pyrazole-4-carboxylic acid ester useful as starting materials in the process of the invention.

REFERENCES:
patent: 2429575 (1971-08-01), Appleby et al.
patent: 3847933 (1974-11-01), Tyler
patent: 3898280 (1975-08-01), Pander
patent: 4589905 (1986-05-01), Beck
Chiu et al., J. Org. Chem., 43(1), 61 (1978).
Chemical Abstracts, 80, 107972x (1974).
Evans et al., Can. J. Chem., 34, 1271 (1956).

Affiliated with

Also associated with

Rating

Alkylation of 3(5)-cyano-1H-pyrazole-4-carboxylic acid esters does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alkylation of 3(5)-cyano-1H-pyrazole-4-carboxylic acid esters, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alkylation of 3(5)-cyano-1H-pyrazole-4-carboxylic acid esters will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-668369