Alkylaminodesoxy-1.4;3.6-dianhydrohexitol nitrates substituted b

Details Alkylaminodesoxy-1.4;3.6-dianhydrohexitol nitrates substituted b Alkylaminodesoxy-1.4;3.6-dianhydrohexitol nitrates substituted b

1981-07-20

1985-09-17

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544268, 544277, 549464, A61K 3152, C07D47308

Patent

active

045421374

ABSTRACT:
Alkylaminodesoxy-1.4;3.6-dianhydrohexitol nitrates substituted by purine bases of the general formula I, ##STR1## wherein R.sup.1 signifies a hydrogen atom or a lower alkyl group with 1 to 4 C-atoms, X a straight-chained or branched alkyl or hydroxyalkyl group with 1 to 7 C-atoms, Y a 1,3-dialkylxanthin-7-yl or a 3,7-dialkylxanthin-1-yl group, each with straight or branched-chained alkyl groups with 1 to 5 C-atoms, or an adenin-9-yl group, as well as their physiologically acceptable acid-addition salts. Process for the preparation of said compounds and pharmaceutical compositions containing said compounds.

REFERENCES:
patent: 2852507 (1958-09-01), Goldman et al.
patent: 4000137 (1976-12-01), Duonch et al.
patent: 4087603 (1978-05-01), Hamill et al.
patent: 4321376 (1982-03-01), Otani et al.
patent: 4413122 (1983-11-01), Klessing
Klessing et al., "Chemical Abstracts", vol. 96, 1982, Col. 96:218190r.

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