Alkylaminoamide compounds

Details Alkylaminoamide compounds Alkylaminoamide compounds

1988-08-08

1991-01-22

Hines, Robert V.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564163, 564164, 564166, A61K 31165, C07C23300

Patent

active

049871536

ABSTRACT:
Novel alkylaminoamides of the formula ##STR1## wherein R is selected from the group consisting of (a) alkyl of 1 to 8 carbon atoms, (b) cycloalkyl of 3 to 7 carbon atoms optionally substituted with phenyl, (c) aryl of 6 to 14 carbon atoms optionally substituted with at least one member of the group consisting of halogen, --CF.sub.3, alkyl of 1 to 6 carbon atoms, --NO.sub.2 and cycloalkyl of 3 to 7 carbon atoms, (d) aralkyl of 7 to 14 carbon atoms and (e) ##STR2## Z is --(CH.sub.2).sub.n -- optionally substituted by an alkyl of 1 to 6 carbon atoms, n is an integer from 1 to 6, Y is --(CH.sub.2).sub.n -- or ##STR3## and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable anti-oedematous and anti-inflammatory activity.

REFERENCES:
patent: 4331816 (1982-05-01), Hadley
Furukawa et al., "Chemical Abstracts", vol. 79, Section 31636x, Column 1 (1973).
Large et al., "Chemical Abstracts", vol. *&, Section No. 117562x, p. 570 (1977).

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