Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di

Details Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di

1993-11-22

1995-07-11

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

564154, A61K 3116, A61K 31165, C07C32341

Patent

active

054322014

ABSTRACT:
Compounds characterized generally as alkylaminoalkyl-terminated .beta.-alanineamide amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of the formula ##STR1## wherein n is two or three; wherein x is a number selected from zero, one and two; wherein R.sup.2 is selected from hydrido, methyl, ethyl and phenyl; wherein R.sup.3 is selected from hydrido, cyclohexylmethyl, benzyl, fluorobenzyl, chlorobenzyl, napthylmethyl, fluoronaphthylmethyl and chloronaphthylmethyl; wherein R.sup.5 is methyl; wherein R.sup.7 is cyclohexylmethyl; wherein R.sup.8 is selected from n-propyl, isobutyl, cyclopropyl, cyclopropylmethyl, allyl and vinyl; and wherein each of R.sup.9 and R.sup.10 is a group independently selected from methyl, ethyl and isopropyl; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 5246969 (1993-09-01), Hanson et al.
patent: 5268391 (1993-12-01), Hanson et al.
patent: 5312838 (1994-05-01), Chen et al.
patent: 5314920 (1994-05-01), Chen et al.

Affiliated with

Also associated with

Rating

Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Alkylaminoalkyl-sulfonyl-terminated .beta.-alanineamide amino-di will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-503795