Alkylamino- and alkylamino alkyl diarylketones

Details Alkylamino- and alkylamino alkyl diarylketones Alkylamino- and alkylamino alkyl diarylketones

1990-07-31

1991-04-09

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514655, 564305, 564384, 564389, 564441, 564442, 564443, A61K 31135, C07C21127, C07C21146, C07C21574

Patent

active

050065637

ABSTRACT:
This invention relates to alkylamino and alkyl amino alkyl diarylketones of the formula ##STR1## where Ar is aryl of the formula ##STR2## where V is hydrogen, halogen, loweralkyl, loweralkoxy, CF.sub.3, No.sub.2 and u is an integer of 1 to 3; X and Y are independently CH.sub.2 --, --CH.sub.2 -- or --CHF--; Z and W are independently --CH.sub.2 --, --O--, --CHOH--, or --CHF--; m, n, p, q and t are integers which are independently 0 or 1; R.sub.1 is H or loweralkyl; R.sub.2 and R.sub.3 are loweralkyl; and the pharmaceutically acceptable acid addition salts thereof and where applicable the geometric and optical isomers and racemic mixtures thereof. The compounds of this invention display utility as analgesic agents and as agents for alleviating various memory dysfunctions, characterized by a decreased cholinergic function, such as Alzheimer's disease.

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Gelb et al., Biochemistry, 24, No. 8, 1813-1817 (1985).
Yamada et al., "Thermal Rearrangement of Optically Active, etc.", CA, 68, p. 1147, #12198n, 1968.

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