Alkylamides of carboxyalkanoyl peptides and method for preparati

Details Alkylamides of carboxyalkanoyl peptides and method for preparati Alkylamides of carboxyalkanoyl peptides and method for preparati

1982-08-09

1985-11-19

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C10352

Patent

active

045541000

ABSTRACT:
A method is described for the preparation of novel alkylamides of carboxyalkanoyl peptides of the formula ##STR1## wherein R is an aralky or an alkyl group of 1-5 carbon atoms, A is a residue of peptidically bound proline or alanine, B is a straight bond or a residue of peptidically bound proline or alanine and X is a CH.dbd.CH group or a methylene group of 1-3 carbon atoms.
The described compounds are capable of inhibiting elastase.

REFERENCES:
patent: 4187216 (1980-02-01), Hassall et al.
Chemical Abstracts, 96, 1982, p. 237, Abstract No. 48067m, Kleine et al.
Hochstrasser et al., Hoppe-Seyler's Z. Physiol. Chem., 362, 1369-1375, (1981).
Bayer, Biochemical and Biophysical Research Communications, 32, No. 5, 739-902, (1968).
K. Blaha, P. Malon, Peptides, Walter de Gruyter & Co., Berlin, 1982, pp. 639-642.
Kasafirek et al., Experientia, vol. 39, 1983, pp. 374-375.
Kasafirek, FEBS Letters, vol. 40, No. 2, 1974, pp. 353-356.
Kasafirek et al., Eur. J. Biochem., vol. 89, 1976, pp. 1-13.

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