Alkyl substituted pyridazinones and pharmaceutical compositions

Details Alkyl substituted pyridazinones and pharmaceutical compositions Alkyl substituted pyridazinones and pharmaceutical compositions

1986-08-06

1987-10-13

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514237, 514238, 514240, 544114, A61K 31535, C07D41310

Patent

active

046999086

ABSTRACT:
The present invention relates to novel 6-phenyl-5-alkyl substituted-4,5-dihydro-3(2H)-pyridazinones of formula I: ##STR1## in which R.sub.1 is halogen, lower alkyl, lower alkoxy, NO.sub.2, NH.sub.2, NHCOR.sub.3 (R.sub.3 is H or C.sub.1 -C.sub.4 alkyl), CN, carboxy, lower alkoxycarbonyl, carbamoyl, CF.sub.3, or OH and R.sub.2 is C.sub.1 -C.sub.4 alkyl; the tautomeric forms and salts thereof; as their racemic mixtures or as the individual optically-active forms.
Compounds (I) are useful in pharmaceutical preparations having improved antithrombotic activity.

REFERENCES:
patent: 3975388 (1976-08-01), Hakim et al.
Curran et al., CA 77:19664f (1972).
Albright et al., CA 90:38855d (1979).

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