Alkyl substituted pyridazinones and pharmaceutical compositions

Details Alkyl substituted pyridazinones and pharmaceutical compositions Alkyl substituted pyridazinones and pharmaceutical compositions

1985-10-22

1986-12-16

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D41310

Patent

active

046297898

ABSTRACT:
The present invention relates to novel 6-phenyl-5-alkyl substituted-4,5-dihydro-3(2H)-pyridazinones of formula I: ##STR1## in which R.sub.1 is halogen, lower alkyl, lower alkoxy, NO.sub.2, NH.sub.2, NHCOR.sub.3 (R.sub.3 is H or C.sub.1 -C.sub.4 alkyl), CN, carboxy, lower alkoxycarbonyl, carbamoyl, CF.sub.3, or OH and R.sub.2 is C.sub.1 -C.sub.4 alkyl; the tautomeric forms and salts thereof; as their racemic mixtures or as the individual optically-active forms.
Compounds (I) are useful in pharmaceutical preparations having improved antithrombotic activity.

REFERENCES:
patent: 3975388 (1976-08-01), Hakim et al.
Curran et al., Chemical Abstracts, vol. 77 (1972) No. 19664f, Substance Index, vol. 77 (1922), p. 3370CS.
Albright et al., Chemical Abstracts, vol. 90 (1979), No. 38855d, Substance Index, vol. 90 (1979), p. 5069CS.

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