Alkyl substituted nitroimidazole acetic acids

Details Alkyl substituted nitroimidazole acetic acids Alkyl substituted nitroimidazole acetic acids

1993-04-20

1994-09-06

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D23391

Patent

active

053449371

ABSTRACT:
This invention provides the substantially pure (R) enantiomer of a compound of the Formula II: ##STR1## The compounds of Formula II are useful in the preparation of the substantially pure (R) enantiomer of angiotensin II antagonists of Formula III: ##STR2## wherein R.sub.1, Ar, R.sub.2 and X are variables.

REFERENCES:
patent: 5073566 (1991-12-01), Lifer et al.
CA 112 (19):178783b Improved . . . nitroimidazoles. Searcey et al., p. 750, 1990.
CA 115(23): 256180f Preparation . . . antagonists. Lifer et al., 1991.
CA 117(3): 26418b Synthesis . . . acids. Suwinski et al., p. 701, 1992.
CA 117(13): 131124a Nitroimidazoles . . . compounds. Suwinski et al., 1992.
Jacques, et al., Enantiomers, Racemeates, and Resolutions, (John Wiley and Sons 1981).

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