Alkyl substituted nitroimidazole acetic acids

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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5483271, C07D23364

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active

053808665

ABSTRACT:
This invention provides the substantially pure (R) enantiomer of a compound of the Formula II: ##STR1## The compounds of Formula II are useful in the preparation of the substantially pure (R) enantiomer of angiotensin II antagonists of Formula III: ##STR2## wherein R.sub.1, Ar, R.sub.2 and X are variables.

REFERENCES:
patent: 4925949 (1990-05-01), Massonneau et al.
patent: 5073566 (1991-12-01), Lifer et al.
Jacques, et al., Enantiomers, Racemates, and Resolutions, (John Wiley and Sons 1981).
CA 112 (19): 178783b Improved . . . nitroimidazoles. Searcey, et al., p. 750 (1990).
CA 115 (23): 256180f Preparation . . . antagonists. Lifer, et al., (1991).
CA 117 (3): 26418b Synthesis . . . arids. Suwinski, et al., p. 701 (1992).
Ca 117 (13): 131124a Nitroimidazoles . . . compounds. Suwinski, et al. (1992).

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