Alkyl substituted indoloquinoxalines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

active

08084453

ABSTRACT:
Novel substituted indoloquinoxalines of formula (IwhereinR1is hydrogen or represents one or more similar or different substituents in the positions 7 to 10 selected from the group halogen, lower alkyl/alkoxy, hydroxy, trifluoromethyl, trichloromethyl, trifluoromethoxy,R2represents similar or different C1-C4alkyl substituents,X is CO or CH2,Y is OH, NH2, NH—(CH2)n—R3wherein R3represents lower alkyl, OH, NH2, NHR4or NR5R6wherein R4, R5and R6independently are lower alkyl or cyclo-alkyl and n is an integer of from 2 to 4,with the provision that when X is CH2, Y is OH or NH—(CH2)n—OH,and pharmacologically acceptable salts thereof are described.The compounds are useful as drugs for preventing and/or treating autoimmune diseases.

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Zawadoski et al, “Synthesis of some 6-substituted derivatives of indophenazine with potential pharmacological activity”, Acta Poloniae Pharmaceutica, vol. 52, No. 3, pp. 249-251 (1995).

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