Alkyl-substituted cellulose-based sustained-release oral drug do

Details Alkyl-substituted cellulose-based sustained-release oral drug do Alkyl-substituted cellulose-based sustained-release oral drug do

1995-05-30

1996-12-10

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424452, 424457, 424464, 424465, 424468, 424489, 514781, 514786, 514951, 514925, A61K 916, A61K 922, A61K 952

Patent

active

055828370

ABSTRACT:
Sustained release oral drug dosage forms that comprise a tablet or capsule containing a plurality of particles of a solid-state drug dispersed in alkyl cellulose such as hydroxyethylcellulose or hydroxypropylcellulose. Once ingested the tablet or capsule disintegrates to disperse the particles into the stomach where they imbibe water to cause them to swell and also to become slippery, thus enhancing their retention in the stomach. Imbibed water from the gastric fluid dissolves the drug entrapped in the particles and the resulting solution diffuses from the dispersed particles, assuring that no solid drug, which with some drugs is more irritating, contacts the mucosal tissue. A number of embodiments of the dosage form utilizing different drugs are exemplified and the benefits are explained. Aspirin is one example.

REFERENCES:
patent: 5007790 (1991-04-01), Shell

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