Alkyl or olefinic endcapped polyalkylene oxide solubilizer

Details Alkyl or olefinic endcapped polyalkylene oxide solubilizer Alkyl or olefinic endcapped polyalkylene oxide solubilizer

1997-07-21

2000-01-11

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

5147723, 525403, A61K 4734, C08G 6532

Patent

active

060132833

ABSTRACT:
A method for rendering water-insoluble materials water-soluble is provided. The method is useful for solubilizing substantially water-insoluble bioactive materials such as drugs. This is accomplished by forming a non-covalently bonded complex between the drug and a polymer which is soluble in both water and an organic solvent. This is carried out by combining the desired medicinal agent with the polymer is an organic solvent, removing the solvent and dissolving the complex in water or aqueous buffer. When the organic solvent is evaporated, a solid complex is recovered which is water-soluble. Methods of treatment with the complexes are also provided.

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