Alkyl or aryl substituted dihydronaphthalene derivatives having

Organic compounds -- part of the class 532-570 series – Organic compounds – Azo

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560100, C07D33324

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active

061179876

ABSTRACT:
Compounds of the formula ##STR1## where the symbols have the meaning describedin the application, have retinoid-like or retinoid antagonist-like biological activity.

REFERENCES:
patent: 4096341 (1978-06-01), Frazer
patent: 4326055 (1982-04-01), Loeliger
patent: 4391731 (1983-07-01), Boller et al.
patent: 4485252 (1984-11-01), Fuchs et al.
patent: 4539154 (1985-09-01), Krebs
patent: 4695649 (1987-09-01), Magami et al.
patent: 4723028 (1988-02-01), Shudo
patent: 4739098 (1988-04-01), Chandraratna
patent: 4740519 (1988-04-01), Shroot et al.
patent: 4810804 (1989-03-01), Chandraratna
patent: 4826969 (1989-05-01), Maignan et al.
patent: 4826984 (1989-05-01), Berlin et al.
patent: 4833240 (1989-05-01), Maignana et al.
patent: 4855320 (1989-08-01), Chatterjee et al.
patent: 4895868 (1990-01-01), Chandraratna
patent: 4923884 (1990-05-01), Chandraratna
patent: 4927947 (1990-05-01), Chandraratna
patent: 4980369 (1990-12-01), Chandraratna
patent: 4992468 (1991-02-01), Chandraratna
patent: 5006550 (1991-04-01), Chandraratna
patent: 5013744 (1991-05-01), Chandraratna
patent: 5015658 (1991-05-01), Chandraratna
patent: 5023341 (1991-06-01), Chandraratna
patent: 5037825 (1991-08-01), Klaus et al.
patent: 5045551 (1991-09-01), Chandraratna
patent: 5053523 (1991-10-01), Chandraratna
patent: 5068252 (1991-11-01), Chandraratna
patent: 5089509 (1992-02-01), Chandraratna
patent: 5130335 (1992-07-01), Chandraratna
patent: 5134159 (1992-07-01), Chandraratna
patent: 5162546 (1992-11-01), Chandraratna
patent: 5175185 (1992-12-01), Chandraratna
patent: 5183827 (1993-02-01), Chandraratna
patent: 5202471 (1993-04-01), Chandraratna
patent: 5231113 (1993-07-01), Chandraratna
patent: 5234926 (1993-08-01), Chandraratna
patent: 5248777 (1993-09-01), Chandraratna
patent: 5264456 (1993-11-01), Chandraratna
patent: 5264578 (1993-11-01), Chandraratna
patent: 5272156 (1993-12-01), Chandraratna
patent: 5278318 (1994-01-01), Chandraratna
patent: 5324744 (1994-06-01), Chandraratna
patent: 5324840 (1994-06-01), Chandraratna
patent: 5326898 (1994-07-01), Chandraratna
patent: 5344959 (1994-09-01), Chandraratna
patent: 5346895 (1994-09-01), Chandraratna
patent: 5346915 (1994-09-01), Chandraratna
patent: 5348972 (1994-09-01), Chandraratna
patent: 5348975 (1994-09-01), Chandraratna
patent: 5349105 (1994-09-01), Chandraratna
patent: 5354752 (1994-10-01), Chandraratna
patent: 5354776 (1994-10-01), Chandraratna
patent: 5380877 (1995-01-01), Chandraratna
patent: 5391753 (1995-02-01), Chandraratna
patent: 5399561 (1995-03-01), Chandraratna
patent: 5399586 (1995-03-01), Davies et al.
patent: 5407937 (1995-04-01), Chandraratna
patent: 5414007 (1995-05-01), Chandraratna
patent: 5420145 (1995-05-01), Shudo
patent: 5426118 (1995-06-01), Chandraratna
patent: 5434173 (1995-07-01), Chandraratna
patent: 5451605 (1995-09-01), Chandraratna et al.
patent: 5455265 (1995-10-01), Chandraratna
patent: 5466861 (1995-11-01), Dawson et al.
patent: 5468879 (1995-11-01), Chandraratna
patent: 5470999 (1995-11-01), Chandraratna
patent: 5475022 (1995-12-01), Chandraratna
patent: 5475113 (1995-12-01), Chandraratna
patent: 5489584 (1996-02-01), Vuligonda et al.
patent: 5498755 (1996-03-01), Chandraratna et al.
patent: 5498795 (1996-03-01), Song et al.
patent: 5514825 (1996-05-01), Vuligonda et al.
patent: 5516904 (1996-05-01), Chandraratna
patent: 5523457 (1996-06-01), Starrett, Jr. et al.
patent: 5534516 (1996-07-01), Chandraratna
patent: 5534641 (1996-07-01), Song et al.
patent: 5543534 (1996-08-01), Vuligonda et al.
patent: 5556996 (1996-09-01), Beard et al.
patent: 5559248 (1996-09-01), Starrett, Jr. et al.
patent: 5563292 (1996-10-01), Sheh et al.
patent: 5591858 (1997-01-01), Vuligonda et al.
patent: 5599819 (1997-02-01), Chandraranta
patent: 5599967 (1997-02-01), Vuligonda et al.
patent: 5602130 (1997-02-01), Chandraranta
patent: 5602135 (1997-02-01), Chandraranta
patent: 5605915 (1997-02-01), Vuligond et al.
patent: 5616597 (1997-04-01), Chandraratna
patent: 5616712 (1997-04-01), Teng et al.
patent: 5618836 (1997-04-01), Chandraratna et al.
patent: 5618931 (1997-04-01), Beard et al.
patent: 5618943 (1997-04-01), Vuligonda et al.
patent: 5648503 (1997-07-01), Vuligonda et al.
patent: 5648514 (1997-07-01), Johnson et al.
patent: 5654469 (1997-08-01), Vuligonda et al.
patent: 5663347 (1997-09-01), Chandraratna
patent: 5663357 (1997-09-01), Teng et al.
patent: 5663367 (1997-09-01), Vuligonda et al.
patent: 5672710 (1997-09-01), Beard et al.
patent: 5675024 (1997-10-01), Teng et al.
patent: 5675033 (1997-10-01), Vuligonda et al.
patent: 5677320 (1997-10-01), Chandraratna
patent: 5677323 (1997-10-01), Chandraratna
patent: 5677451 (1997-10-01), Chandraratna
patent: 5688957 (1997-11-01), Teng et al.
patent: 5696162 (1997-12-01), Chandraratna
patent: 5698700 (1997-12-01), Song et al.
patent: 5717094 (1998-02-01), Chandraratna
patent: 5723620 (1998-03-01), Vuligonda et al.
patent: 5723666 (1998-03-01), Vuligonda et al.
patent: 5728846 (1998-03-01), Vuligonda et al.
patent: 5739338 (1998-04-01), Beard et al.
patent: 5741896 (1998-04-01), Vuligonda et al.
patent: 5776699 (1998-07-01), Klein
A General Synthesis of Terminal and Internal Arylalkynes by the Palladium-Catalyzed Reaction of Alkylnylzinc Reagents with Aryl Halides by Anthony O. King and Ei-ichi, J. Org. Chem., (1978) 43/2: p. 358.
Conversion of Methyl Ketones into Terminal Acetylenes and (E)-Tri-substituted Olefins of Terpenoid Origin by Ei-ichi, et al., J. Org. Chem., (1980) 45/12: p.2526.
Sporn et al. in J. Amer. Acad. Derm.., (1986) 15:756-764.
"A Convenient Synthesis of Ethynylarenes and Diethylnylarenes" by S. Takahashi et al. Synthesis (1980) p.627-630.
Shudo et al. in Chem. Pharm. Bull.,(1988) 31:2182-2192.
Kagechika et al. in J. Med. Chem., (1988) 31:2182-2192.
Chemistry and Biology of Synthetic Retinoids by Marcia I. Dawson and William H. Okamura, published by CRC Press Inc., 1990, p.334-335, 354.
Syntheisi of 2,2'-Diacyl-1,1'-Biaryls. Regiocontrolled Protection of . . . by Mervic, et al, J. Org. Chem., (1980) No. 45, p.4720-4725.
A Dopamine Receptor Model and Its Application in the Design of a New Class of Rigid Pyrrolo [2,3-g] isoquinoline Antipsychotics, Gary L. Olson et al. American Chemical Societe, (1981) 24/9:1026-1031.
6.2.3 Conformational Restriction, Williams, et al., Drug Discovery and Development, The Human a Press, (1987) pp. 54-55.
V. Retinoid Structure-Biological Activity Relationships, Chemistry and Biology of Synthetic Retinoids, (1990) pp. 324-356.
Davis et al. J. Organomettalic Chem (1990) 387:381-390.
"Effects of 13-Cis-Retinoic Acid, All Trans-Retinoic Acid, and Acitretin on the Proliferation, Lipid Synthesis and Keratin Expression of Cultured Human Sebocytes in Vitro" C.C. Zouboulis, The Journal of Investigative Dermatology, (1991) 96/5:792-797.
"Organ Maintenance of Human Sebaceous Glands: in Vitro Effects of 13-Cis Retinoic Acid and Testosterone", John Ridden, et al., Journal of Cell Science (1990) 95:125-136.
"Characterization of Human Sebaceous Cells in Vitro", Thomas I. Doran, et al. The Journal of Investigative Dermatology, (1991) 96/3:.
"Synthesis and Evaluation of Stilbene and Dihydrostilbene Derivateives as Potential Anticancer Agents That Inhibit Tubulin Polymerization" by Cushman, Mark et al. J. Med. Chem., (1991), 34:2579-2588.
"Synthesis and Evaluationof New Pretoein Tyrosine Kinase Inhibitors. Part 1. Pyridine-Containing Stilbenes and Amides" by Cushman, Mark et al. Bioorganic & Medicinal Chemistry Letters, (1991) 1/4:211-214.
"Di-and Tri-methoxystyryl Derivatives of Heterocyclic Nitrogen Compounds" by Bahner, C. T. et al. Arzneim-Forsch./Drug Res, (1981)31 (I), Nr. 3.
"Retinobenzoic acids. 3. Structure-Activity Relationships of Retinoidal Azobenzene-4-Carboxylic Acids and Stilbene-4-Carboxylic Acids" by H. Kagechika et al., Journal of Medicinal Chemistry, (1989), 32:1098-1108.
Eyrolles, L. et al. "Retinoid Antagonists: Molecular Design Based on the Ligand Superfamily Concept" Med. Chem. Res., (1992) 2:361-367.
Liu, S. S. et al. "Systemic Pharmacokinetics of Acetylenic Retinoids in Rats", Drug Metabolism and Disposition, (1990) 18/6: 1071-1077.
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