Alkyl or alkoxy substituted S-heterocyclic retinoids

Details Alkyl or alkoxy substituted S-heterocyclic retinoids Alkyl or alkoxy substituted S-heterocyclic retinoids

1993-05-05

1995-02-21

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33506, A61K 3138

Patent

active

053917669

ABSTRACT:
Compounds of the formula ##STR1## in which X is --S--, --SO-- or --SO.sub.2 --; R.sup.1 is C.sub.7-10 -alkyl or C.sub.7-10 -alkoxy; R.sup.2 is a residue of the formula ##STR2## R.sup.3 is carboxy or lower-alkoxycarbonyl; and n is an integer of 1, 2 or 3; and salts of carboxylic acids of formula I can be used for the treatment of autoimmune diseases and diseases having a strong immunological component, such as psoriasis.

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Frierson, et al., "Computer-Automated Structure Evaluation of Retinoids in Teratogenesis Bioassays", Fundam. Appl. Toxicol, 14, pp. 408-428 (1990).
Lehmann, et al., "Identification of Retinoids with Nuclear Receptor Subtype-Selective Activities", Cancer Research, 51, pp. 4804-4809, (1991).

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