Alkyl or alkoxy substituted S-heterocyclic retinoids

Details Alkyl or alkoxy substituted S-heterocyclic retinoids Alkyl or alkoxy substituted S-heterocyclic retinoids

1994-10-18

1996-04-30

Robinson, Allen J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33704

Patent

active

055126839

ABSTRACT:
Compounds of the formula ##STR1## in which X is --S--, --SO-- or --SO.sub.2 --; R.sup.1 is C.sub.7-10 -alkyl or C.sub.7-10 -alkoxy; R.sup.2 is a residue of the formula ##STR2## R.sup.3 is carboxy or lower-alkoxycarbonyl; and n is an integer of 1, 2 or 3; and salts of carboxylic acids of formula I can be used for the treatment of autoimmune diseases and diseases having a strong immunological component, such as psoriasis.

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Apfel, et al., Proc. Natl. Acad. Sci., 89:7129-7133, (Aug. 1992) "A Retinoic Acid Receptor Alpha Antagonist Selectively Counteracts Retinoic Acid Effects".
Frierson, et al, "Computer-Automated Structure Evaluation of Retinoids In Teratogensis Bioassays", Fundam, Appl. Toxicol, 14, pp. 408-428 (1990).
Lehmann, et al, "Idenification Of Retinoids With Nuclear Receptor Subtype-Selective Activities", Cancer Research, 51, pp. 4804-4809, (1991).

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