Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,... – Conjugated via claimed linking group – bond – chelating agent,...
Patent
1978-08-04
1980-04-29
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
Conjugated via claimed linking group, bond, chelating agent,...
424279, 260,41, 536 17A, C07H 1708, C07D49322, A61K 3171, A61K 31365
Patent
active
042005817
ABSTRACT:
Derivatives of C-076, a series of macrolides are described, in which the substituents are hydrocarbon groups. The hydrocarbon groups generally are alkyl groups which may be straight or branched and may optionally be substituted with phenyl. The substituted C-076 compounds are prepared by various procedures depending upon the position of the reaction site, and the particular C-076 compound being substituted. The compounds have profound anthelmintic, insecticidal, ectoparasiticidal and acaracidal activity and compositions for such uses are also disclosed.
REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
Mishima et al. Tetrahedron letters 10, pp. 711-714, 1975.
Journal of Antibiotics 29(6) Jun. 1976, pp. 76-34 to 76-42 and pp. 76-14 to 76-16.
Fisher Michael H.
Lusi Aino
Tolman Richard L.
Fan Jane T.
Jiles Henry R.
Merck & Co. , Inc.
Rose David L.
Westlake Harry E.
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